LL-37
Catalog No:CP-LL37-002A
Manufacturer:CPC Scientific
Size:1 mg
CAS No.:154947-66-7
Formula:C205H340 N60O53
MWt:4,493
€312,00
Product Name: | LL-37 |
Category: | Peptides |
Three letter sequence: | H-Leu-Leu- Gly-Asp-Phe- Phe-Arg-Lys- Ser-Lys-Glu- Lys-Ile-Gly- Lys-Glu-Phe- Lys-Arg-Ile- Val-Gln-Arg- Ile-Lys-Asp- Phe-Leu-Arg- Asn-Leu-Val- Pro-Arg-Thr- Glu-Ser-OH Trifluoroacet ate salt |
One letter sequence: | LLGDFFRKSKE KIGKEFKRIVQ RIKDFLRNLVP RTES |
Description: | LL-37 is an antimicrobial peptide with angiogenic activity. It corresponds to the C-terminal sequence (134-170) of the human cathelicidin antimicrobial protein hCAP18/LL-37 and is extracellularly released from hCAP18/LL-37 by proteolytic processing. hCAP18/LL-37 is an effector of the innate immune system and is expressed in leukocytes and epithelial cells where it is upregulated in association with inflammation and injury. An overexpression of hCAP18/LL-37 in a |
Literature References: | Z.Oren et al., Biochem. J., 341, 501 (1999) R.Koczulla et al., J. Clin. Invest., 111, 1665 (2003) R.Shaykhiev et al., Am. J. Physiol. Lung Cell. Mol. Physiol., 289, L842 (2005) J.D.Heilborn et al., Int. J. Cancer, 114, 713 (2005) G.H. Gudmundsson et al.,Eur. J. Biochem., 238, 325 (1996). R. Bals et al., Cell. Mol. Life Sci., 60, 711 (2003) M. Zanetti, J. Leukoc. Biol., 75, 39 (2004) P.T. Liu et al., Science, 311, 770 |
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