Adeno- Associated Virus Epitope 2 (AAV2)
Catalog No:CP-AAV2-001A
Manufacturer:CPC Scientific
Size:1 mg
CAS No.:N/A
Formula:N/A
MWt:1,053
€77,00
Product Name: | Adeno- Associated Virus Epitope 2 (AAV2) |
Category: | Peptides |
Three letter sequence: | Val-Pro-Gln- Tyr-Gly-Tyr- Leu-Thr-Leu |
One letter sequence: | VPQYGYLTL- OH |
Description: | This peptide is the CD8 T cell epitope from adeno- associated virus 2 (AAV2) capsid. Liver toxicity observed in a clinical trial of AAV2 delivered systemically to patients with hemophilia was ascribed to killing of vector-transduced hepatocytes by capsid-specific T- cells. |
Literature References: | Murphy, S. et al. Blood (ASH Annual Meeting Abstracts), 108 (2006) Mingozzi, F. et al. Nature Medicine 10.1038/nm1549 (2007) Wang, L. et al. Therapy. 18, 185 (2007). |
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