Amyloid β/A4 Protein Precursor770 (740-770)
Catalog No:CP-AMYD-049A
Manufacturer:CPC Scientific
Size:1 mg
CAS No.:N/A
Formula:C162H243 N45O52S 2
MWt:3,717
€274,00
Product Name: | Amyloid 尾/A4 Protein Precursor770 (740-770) |
Category: | Peptides |
Three letter sequence: | Ala-Ala-Val- Thr-Pro-Glu- Glu-Arg-His- Leu-Ser-Lys- Met-Gln-Gln- Asn-Gly-Tyr- Glu-Asn-Pro- Thr-Tyr-Lys- Phe-Phe- Glu-Gln-Met- Gln-Asn Trifluoroacet ate salt |
One letter sequence: | AAVTPEERHLS KMQQNGYENP TYKFFEQMQN |
Description: | This peptide is the C- terminal fragment of amyloid precursor protein (APP) also known as C31. It is intracellularly generated by proteolytic cleavage of APP by caspases- 8 and -9. C31 had a proapoptotic and a cytotoxic effect on neuronal cells and was shown to be present in brains of Alzheimer’s disease (AD) patients. In cultured cells caspase cleavage of APP was induced by amyloid 尾-protein and the subsequent generation of C31 contributed to the apoptotic cell death associated with amyloid 尾-protein. |
Literature References: | D.C.Lu et al., Nat. Med., 6, 397 (2000) C.Dumanchin- Njock et al., J. Neurochem., 78, 1153 (2001) V.Galvan et al., J. Neurochem., 82, 283 (2002) Y.Chen et al., J. Cell Biol., 163, 27 (2003) D.C.Lu et al., J. Neurochem., 87, 733 (2003) |
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