Amyloid β/A4 Protein Precursor770 (135-155)
Catalog No:CP-AMYD-048A
Manufacturer:CPC Scientific
Size:0.5 mg
CAS No.:315229-44-8
Formula:C116H173 N35O31S 2
MWt:2,618
€89,00
Product Name: | Amyloid 尾/A4 Protein Precursor770 (135-155) |
Category: | Peptides |
Three letter sequence: | Phe-Leu-His- Gln-Glu-Arg- Met-Asp-Val- Cys-Glu-Thr- His-Leu-His- Trp-His-Thr- Val-Ala-Lys |
One letter sequence: | FLHQERMDVC ETHLHWHTVA K |
Description: | This peptide comprises a Cu2+- binding site. Binding of Cu2+ to the peptide induced oxidation of the cysteine and intermolecular dimerization of the peptide. The reduction of Cu2+ to Cu+ by Amyloid 尾/A4 Protein Precursor may enhance the production of hydroxyl radicals which in turn may contribute to neurodegeneration in Alzheimer’s disease. |
Literature References: | G.Multhaup et al., Science, 271, 1406 (1996) |
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