Urocortin, human
Catalog No:CP-UROC-001B
Manufacturer:CPC Scientific
Size:1 mg
Formula:C204H337 N63O64
MWt:4,696
€220,00
Product Name: | Urocortin, human |
Category: | Peptides |
Three letter sequence: | Asp-Asn-Pro- Ser-Leu-Ser- Ile-Asp-Leu- Thr-Phe-His- Leu-Leu-Arg- Thr-Leu-Leu- Glu-Leu-Ala- Arg-Thr-Gln- Ser-Gln-Arg- Glu-Arg-Ala- Glu-Gln-Asn- Arg-Ile-Ile- Phe-Asp-Ser- Val-NH2 |
One letter sequence: | DNPSLSIDLTFH LLRTLLELART QSQRERAEQN RIIFDSV-NH2 |
Description: | Peptide that binds with high affinity to CRF receptor types 1, 2a & 2b, stimulates cAMP accumulation from cells transfected with those receptors, and acts in vitro to releaes ACTH from dispersed rat anterior pituitary cells. In using a genomic library, the human urocortin has been cloned and localized to human chromosome 2. It has also been discovered that both human and rat urocortin share 95% identity within the mature peptide region. |
Literature References: | C.J. Donaldson et al., Endocrinology, 137, 2167 (1996) |
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