Decanoyl-Arg- Val-Lys-Arg- chloromethylke tone
Catalog No:CP-CASP-089B
Manufacturer:CPC Scientific
Size:1 mg
CAS No.:[ 150113-99-8
Formula:C34H66Cl N11O5
MWt:744
€232,00
Product Name: | Decanoyl-Arg- Val-Lys-Arg- chloromethylke tone |
Category: | Peptides |
Three letter sequence: | Decy-Arg- Val-Lys-Arg- CMK |
One letter sequence: | Decy-RVKR- CMK |
Description: | Peptidyl chloromethylketone that binds to the catalytic site of furin and thus inhibits cleavage and fusion activity of viral glycoproteins, as well as virus replication. This compound also decreases the production of b- amyloid-induced active matrix metalloproteinase 2 in U87 cells. Furthermore, other than furin N-1505 the protein also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication). |
Literature References: | W.Garten et al., Virology , 172, 25 (1989) A.Stieneke-Gr枚ber et al., EMBO J. , 11, 2407 (1992) S.Hallenberger et al., Nature , 360, 358 (1992) W.Garten et al., Biochimie , 76, 217 (1994) J.-B.Denault et al., FEBS Lett. , 362, 276 (1995) J.-B.Denault et al., J. Cardiovasc. Pharmacol. , 26 (Suppl.3), S47 (1995) S.Hallenberger et |
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