Western blot analysis of extracts of various cell lines, using AXIN2 antibody (A13373) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
AXIN2 Rabbit pAb
Catalog No:AB-A13373
Manufacturer:ABclonal
Synonyms:AXIN2;AXIL;ODCRCS;axin-2
Applications:WB
Reactivity:Human,Mouse
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | AXIN2 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human AXIN2 (NP_004646.3). |
Gene ID: | 8313 |
Swiss prot: | Q9Y2T1 |
Molecular weight: | 93kDa |
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