Bisdemethoxycurcumin [Cas No. 24939-16-0]
Catalog No：TA-TL0007
Manufacturer：TargetMol
Synonyms：Didemethoxycurcumin,Curcumin III
CAS No.：24939-16-0
Formula：C19H16O4
MWt：308.33
€45,00 – €225,00
| Name: | Bisdemethoxycurcumin |
| Category: | Biochemicals |
| Description: | Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression [3]. |
| Pathway: | Chromatin/Epigenetic,Cytoskeletal Signaling |
| Target: | Epigenetic Reader Domain inhibitor,Wnt/beta-catenin inhibitor |
| Receptor: | p300,Wnt/β-catenin |
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