Topovale [Cas No. 500214-53-9]
Catalog No:TA-T9088
Manufacturer:TargetMol
Synonyms:Topoval,ARC 111,ARC111,ARC-111
CAS No.:500214-53-9
Formula:C23H23N3O5
MWt:421.45
€98,00 – €2.290,00
Name: | Topovale |
Category: | Biochemicals |
Description: | Topovale is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells. |
Pathway: | DNA Damage/DNA Repair |
Target: | Topoisomerase |
Receptor: | topoisomerase I |
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