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Western blot analysis of extracts of HepG2 cells, using Cation-independent M6PR (Cation-independent M6PR (IGF2R)) antibody (A13022) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 60s.
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Immunohistochemistry of paraffin-embedded human placenta using Cation-independent M6PR (Cation-independent M6PR (IGF2R)) antibody (A13022) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human gastric cancer using Cation-independent M6PR (Cation-independent M6PR (IGF2R)) antibody (A13022) at dilution of 1:100 (40x lens).
Cation-independent M6PR (IGF2R) Rabbit pAb
Catalog No：AB-A13022
Manufacturer：ABclonal
Synonyms：IGF2R;CD222;CI-M6PR;CIMPR;M6P-R;M6P/IGF2R;MPR 300;MPR1;MPR300;MPRI
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | Cation-independent M6PR (IGF2R) Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2327-2491 of human Cation-independent M6PR (Cation-independent M6PR (IGF2R)) (NP_000867.2). |
| Gene ID: | 3482 |
| Swiss prot: | P11717 |
| Molecular weight: | 274kDa |
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