Xevinapant [Cas No. 1071992-99-8]
Catalog No:TA-T6763
Manufacturer:TargetMol
Synonyms:Debio-1143,SM-406,ARRY-334543
CAS No.:1071992-99-8
Formula:C32H43N5O4
MWt:561.71
€36,00 – €1.390,00
Name: | AT406 |
Category: | Biochemicals |
Description: | AT406 (SM-406, ARRY-334543) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1. |
Pathway: | Apoptosis |
Target: | IAP antagonist |
Receptor: | cIAP1-BIR3, cIAP2-BIR3, XIAP-BIR3 |
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