Xevinapant [Cas No. 1071992-99-8]
Catalog No：TA-T6763
Manufacturer：TargetMol
Synonyms：Debio-1143,SM-406,ARRY-334543
CAS No.：1071992-99-8
Formula：C32H43N5O4
MWt：561.71
€36,00 – €1.390,00
| Name: | AT406 |
| Category: | Biochemicals |
| Description: | AT406 (SM-406, ARRY-334543) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1. |
| Pathway: | Apoptosis |
| Target: | IAP antagonist |
| Receptor: | cIAP1-BIR3, cIAP2-BIR3, XIAP-BIR3 |
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