Galeterone [Cas No. 851983-85-2]
Catalog No：TA-T6509
Manufacturer：TargetMol
Synonyms：VN-124-1,TOK-001,VN/124-1,VN 124
CAS No.：851983-85-2
Formula：C26H32N2O
MWt：388.55
€58,00 – €593,00
| Name: | Galeterone |
| Category: | Biochemicals |
| Description: | Galeterone is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an androgen receptor antagonist, 2) as a CYP17 lyase inhibitor and 3) by decreasing overall androgen receptor levels in prostate cancer tumors, all of which may result in a decrease in androgen-dependent growth signaling. Localized to the endoplasmic reticulum (ER), the cytochrome P450 enzyme CYP17 (P450C17 or CYP17A1) exhibits both 17alpha-hydroxylase and 17, 20-lyase activities, and plays a key role in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. |
| Pathway: | Endocrinology/Hormones, Metabolism |
| Target: | Androgen Receptor antagonist, P450 antagonist |
| Receptor: | Androgen Receptor, CYP17 |
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