CYC-116 [Cas No. 693228-63-6]
Catalog No：TA-T6458
Manufacturer：TargetMol
CAS No.：693228-63-6
Formula：C18H20N6OS
MWt：368.46
€51,00 – €898,00
| Name: | CYC116 |
| Category: | Biochemicals |
| Description: | CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1. |
| Pathway: | Cell Cycle/Checkpoint, Angiogenesis, PI3K/Akt/mTOR signaling, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, MAPK |
| Target: | Aurora Kinase inhibitor, CDK inhibitor, FLT inhibitor, S6 Kinase inhibitor, VEGFR inhibitor |
| Receptor: | Aurora A, Aurora B, CDK2/CyclinE, CDK9/CyclinT, FLT3, p70 S6K, VEGFR2 |
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