Clevudine [Cas No. 163252-36-6]
Catalog No：TA-T6446
Manufacturer：TargetMol
Synonyms：Levovir,L-FMAU
CAS No.：163252-36-6
Formula：C10H13FN2O5
MWt：260.22
€33,00 – €409,00
| Name: | Clevudine |
| Category: | Biochemicals |
| Description: | Clevudine is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase). Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA), therefore the patient is less likely to have a relapse after treatment is discontinued. |
| Pathway: | DNA Damage/DNA Repair |
| Target: | DNA/RNA Synthesis inhibitor |
| Receptor: | DNA polymerase, RNA polymerase |
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