Tosedostat [Cas No. 238750-77-1]
Catalog No:TA-T6301
Manufacturer:TargetMol
Synonyms:CHR-2797
CAS No.:238750-77-1
Formula:C21H30N2O6
MWt:406.47
€50,00 – €926,00
Name: | Tosedostat |
Category: | Biochemicals |
Description: | CHR-2797 is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. CHR-2797 is converted intracellularly into a poorly membrane-permeable active metabolite (CHR-79888) which inhibits the M1 family of aminopeptidases, particularly puromycin-sensitive aminopeptidase (PuSA), and leukotriene A4 (LTA4) hydrolase, inhibition of these aminopeptidases in tumor cells may result in amino acid deprivation, inhibition of protein synthesis due to a decrease in the intracellular free amino acid pool, an increase in the level of the proapoptotic protein Noxa, and cell death. |
Pathway: | Metabolism |
Target: | Aminopeptidase |
Receptor: | M1-aminopeptidase |
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