Bosentan [Cas No. 147536-97-8]
Catalog No：TA-T6264
Manufacturer：TargetMol
Synonyms：Benzenesulfonamide,Ro 47-0203,Actelion
CAS No.：147536-97-8
Formula：C27H29N5O6S
MWt：551.61
€50,00 – €327,00
| Name: | Bosentan |
| Category: | Biochemicals |
| Description: | Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension. |
| Pathway: | GPCR/G Protein |
| Target: | Endothelin Receptor antagonist |
| Receptor: | ET-A, ET-B |
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