Avagacestat [Cas No. 1146699-66-2]
Catalog No：TA-T6249
Manufacturer：TargetMol
Synonyms：BMS-708163
CAS No.：1146699-66-2
Formula：C20H17ClF4N4O4S
MWt：520.88
€57,00 – €1.890,00
| Name: | Avagacestat |
| Category: | Biochemicals |
| Description: | Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2. |
| Pathway: | Proteases & Proteasome,Neuroscience,Stem Cells |
| Target: | Gamma-secretase inhibitor |
| Receptor: | γ secretase(Aβ42) , γ secretase(Aβ40) |
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