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Western blot analysis of extracts of various cell lines, using NLRP3 Rabbit pAb (A12694) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 180s.
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Immunohistochemistry of paraffin-embedded human appendix using NLRP3 antibody (A12694) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded rat lung using NLRP3 antibody (A12694) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse spleen using NLRP3 antibody (A12694) at dilution of 1:100 (40x lens).
NLRP3 Rabbit pAb
Catalog No：AB-A12694
Manufacturer：ABclonal
Synonyms：NLRP3;AGTAVPRL;AII;AVP;C1orf7;CIAS1;CLR1.1;FCAS;FCAS1;FCU;MWS;NALP3;PYPAF1
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | NLRP3 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5′ UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5′ UTR splice patterns are biologically valid. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 900 to the C-terminus of human NLRP3 (NP_001120934.1). |
| Gene ID: | 114548 |
| Swiss prot: | Q96P20 |
| Molecular weight: | 83kDa/105kDa/111kDa/112kDa/115kDa/118kDa |
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