WHI-P97 [Cas No. 211555-05-4]
Catalog No:TA-T4657
Manufacturer:TargetMol
CAS No.:211555-05-4
Formula:C16H13Br2N3O3
MWt:455.1
€41,00 – €1.350,00
Name: | WHI-P97 |
Category: | Biochemicals |
Description: | WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. WHI-P97 did not directly inhibit the enzymatic activity of 5-LO, but prevented its translocation to the nuclear membrane without affecting the requisite calcium signal. |
Pathway: | Angiogenesis/Chromatin/Epigenetic/Chromatin/Epigenetic/Stem Cells |
Target: | JAK |
Receptor: | JAK3 |
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