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Western blot analysis of extracts of various cell lines, using TIRAP antibody (A12606) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
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Immunohistochemistry of paraffin-embedded mouse kidney using TIRAP antibody (A12606) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded rat kidney using TIRAP antibody (A12606) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse liver using TIRAP antibody (A12606) at dilution of 1:100 (40x lens).
TIRAP Rabbit pAb
Catalog No：AB-A12606
Manufacturer：ABclonal
Synonyms：TIRAP;BACTS1;Mal;MyD88-2;wyatt
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | TIRAP Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human TIRAP (NP_001034750.1). |
| Gene ID: | 114609 |
| Swiss prot: | P58753 |
| Molecular weight: | 23kDa/25kDa/27kDa |
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