AG126 [Cas No. 118409-62-4]
Catalog No：TA-T4092
Manufacturer：TargetMol
Synonyms：Tyrphostin AG126
CAS No.：118409-62-4
Formula：C10H5N3O3
MWt：215.17
€30,00 – €947,00
| Name: | AG 126 |
| Category: | Biochemicals |
| Description: | The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vivo, attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 μM) and platelet-derived GFRK (IC50 > 100 μM). |
| Pathway: | Immunology & Inflammation, MAPK, Neuroscience |
| Target: | COX inhibitor, ERK inhibitor |
| Receptor: | COX-2, ERK1,2 |
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