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Western blot analysis of extracts of mouse brain, using UHRF1 antibody (A12589) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.
UHRF1 Rabbit pAb
Catalog No：AB-A12589
Manufacturer：ABclonal
Synonyms：UHRF1;ICBP90;Np95;RNF106;TDRD22;hNP95;hUHRF1;huNp95
Applications：WB
Reactivity：Mouse
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | UHRF1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 139-298 of human UHRF1 (NP_037414.3). |
| Gene ID: | 29128 |
| Swiss prot: | Q96T88 |
| Molecular weight: | 89kDa/91kDa |
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