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Western blot analysis of extracts of various cell lines, using MAPKBP1 antibody (A12576) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
MAPKBP1 Rabbit pAb
Catalog No：AB-A12576
Manufacturer：ABclonal
Synonyms：MAPKBP1;JNKBP-1;JNKBP1;NPHP20
Applications：WB
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | MAPKBP1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAPKBP1 (NP_001122080.1). |
| Gene ID: | 23005 |
| Swiss prot: | O60336 |
| Molecular weight: | 23kDa/109kDa/134kDa/149kDa/163kDa |
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