Emedastine [Cas No. 87233-61-2]
Catalog No：TA-T3979
Manufacturer：TargetMol
Synonyms：LY188695,Emadine
CAS No.：87233-61-2
Formula：C17H26N4O
MWt：302.42
€31,00 – €982,00
| Name: | Emedastine |
| Category: | Biochemicals |
| Description: | Emedastine is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic, dopamine, or serotonin receptors. |
| Pathway: | GPCR/G Protein, Immunology & Inflammation, Neuroscience |
| Target: | Histamine Receptor antagonist |
| Receptor: | H1 receptor |
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