Lasmiditan [CAS 439239-90-4]
Catalog No:TA-T3704
Manufacturer:TargetMol
Synonyms:LY573144,COL-144
CAS No.:439239-90-4
Formula:C19H18F3N3O2
MWt:377.14
€94,00 – €974,00
Name: | Lasmiditan |
Category: | Biochemicals |
Description: | Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study. Lasmiditan showed efficacy in its primary endpoint, with a 2-hour placebo-subtracted headache response of 28.8%, though with frequent reports of dizziness, paresthesias, and vertigo. |
Pathway: | GPCR/G Protein, Neuroscience |
Target: | 5-HT Receptor agonist |
Receptor: | 5-HT1F |
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