MCC950 [Cas No. 210826-40-7]
Catalog No:TA-T3701
Manufacturer:TargetMol
Synonyms:CP-456773
CAS No.:210826-40-7
Formula:C20H24N2O5S
MWt:404.48
€42,00 – €612,00
Name: | MCC950 |
Category: | Biochemicals |
Description: | CP-456773 (MCC950 and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and caspase 1 processing. MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes. MCC950 reduced IL-1β production in vivo and attenuated the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. |
Pathway: | Immunology & Inflammation, NF-κB |
Target: | NOD inhibitor |
Receptor: | NLRP3, NLRP3 |
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