(E)-SIS3 [Cas No. 521984-48-5]
Catalog No：TA-T3636
Manufacturer：TargetMol
Synonyms：SIS3 HCl
CAS No.：521984-48-5
Formula：C28H27N3O3﹞HCl
MWt：489.99
€59,00 – €1.550,00
| Name: | SIS3 |
| Category: | Biochemicals |
| Description: | SIS3, a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts and inhibits TGF-β2-induced endothelial cell differentiation in iPSCs. |
| Pathway: | Stem Cells |
| Target: | TGF-beta/Smad inhibitor |
| Receptor: | Smad3 |
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