PF-04418948 [Cas No. 1078166-57-0]
Catalog No:TA-T3306
Manufacturer:TargetMol
Synonyms:PF 04418948,PF-04418948
CAS No.:1078166-57-0
Formula:C23H20FNO5
MWt:409.41
€50,00 – €677,00
Name: | PF04418948 |
Category: | Biochemicals |
Description: | PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors, exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP, reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM). |
Pathway: | GPCR/G Protein |
Target: | Prostaglandin Receptor inhibitor |
Receptor: | PGE2 |
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