Avitinib [Cas No. 1557267-42-1]
Catalog No：TA-T3024
Manufacturer：TargetMol
Synonyms：AC0010
CAS No.：1557267-42-1
Formula：C26H26FN7O2
MWt：487.53
€60,00 – €668,00
| Name: | Avitinib |
| Category: | Biochemicals |
| Description: | Avitinib, also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR, including the drug-resistant T790M EGFR mutant, which prevents signaling mediated by mutant forms of EGFR. This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells. EGFR, a receptor tyrosine kinase that is mutated in a variety of Ys, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR. |
| Pathway: | Angiogenesis,JAK/STAT signaling,Tyrosine Kinase/Adaptors,Chromatin/Epigenetic,Stem Cells |
| Target: | EGFR inhibitor,JAK,BTK |
| Receptor: | EGFR,JAK3,BTK |
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