Negletein [Cas No. 29550-13-8]
Catalog No：TA-T2S0843
Manufacturer：TargetMol
Synonyms：7-O-Methylbaicalein,Baicalein-7-methylether
CAS No.：29550-13-8
Formula：C16H12O5
MWt：284.26
€128,00 – €2.790,00
| Name: | Negletein |
| Category: | Biochemicals |
| Description: | 1. Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. 3. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. 4. Negletein shows significant antimicrobial activity. 5. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.6. Negletein has anti- Alzheimer’s disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. 7. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor. |
| Pathway: | Apoptosis,Immunology & Inflammation |
| Target: | TNF,NOS,IL Receptor |
| Receptor: | TNF-α, iNOS:IL-1β |
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