Bardoxolone [Cas No. 218600-44-3]
Catalog No:TA-T2915
Manufacturer:TargetMol
Synonyms:RTA 401,CDDO
CAS No.:218600-44-3
Formula:C31H41NO4
MWt:491.7
€55,00 – €274,00
Name: | Bardoxolone |
Category: | Biochemicals |
Description: | CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM. By suppressing reactive oxygen and nitrogen species (ROS/RNS) formation, it promotes the cellular control of ROS/RNS levels that would lead to DNA damage associated with tumorigenesis. In various Y cell lines, CDDO has been shown to specifically inhibit proliferation and induce apoptosis. Mechanism studies revealed that CDDO is a ligand for peroxisome proliferator-activated receptor γ, and also that it induces genes regulated by Nrf2, including heme oxygenase-1 and eotaxin-1, which play a role in antioxidant response element signaling activity. |
Pathway: | Immunology & Inflammation |
Target: | Nrf2 inhibitor |
Receptor: | Nrf2 |
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