Western blot analysis of extracts of A-431 cells, using Granulin antibody (A12440) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 180s.
Granulin Rabbit pAb
Catalog No:AB-A12440
Manufacturer:ABclonal
Synonyms:GRN;CLN11;GEP;GP88;PCDGF;PEPI;PGRN;granulins
Applications:WB,IHC,IF
Reactivity:Human,Mouse
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | Granulin Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 281-336 of human Granulin (NP_002078.1). |
Gene ID: | 2896 |
Swiss prot: | P28799 |
Molecular weight: | 44kDa/46kDa/63kDa |
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