Ivabradine hydrochloride [Cas No. 148849-67-6]
Catalog No:TA-T2535
Manufacturer:TargetMol
Synonyms:Ivabradine HCl,S 16257-2
CAS No.:148849-67-6
Formula:C27H37ClN2O5
MWt:505.05
€41,00 – €608,00
Name: | Ivabradine hydrochloride |
Category: | Biochemicals |
Description: | Ivabradine hydrochloride is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity. Upon administration, ivabradine selectively binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial (SA) node. This inhibits the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity and slows diastolic depolarization. |
Pathway: | Neuroscience, GPCR/G Protein |
Target: | Adrenergic Receptor inhibitor |
Receptor: | Adrenergic Receptor |
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