VER-246608 [Cas No. 1684386-71-7]
Catalog No:TA-T17224
Manufacturer:TargetMol
CAS No.:1684386-71-7
Formula:C28H23ClF2N4O4
MWt:552.96
€68,00 – €2.879,00
Name: | VER-246608 |
Category: | Biochemicals |
Description: | VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin. |
Pathway: | PI3K/Akt/mTOR signaling |
Target: | PDK |
Receptor: | PDK1,PDK2,PDK3,PDK4 |
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