TX1-85-1 [Cas No. 1603845-32-4]
Catalog No:TA-T17182
Manufacturer:TargetMol
CAS No.:1603845-32-4
Formula:C32H36N8O3
MWt:580.68
€112,00 – €1.274,00
Name: | TX1-85-1 |
Category: | Biochemicals |
Description: | TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. |
Pathway: | Angiogenesis,JAK/STAT signaling,Tyrosine Kinase/Adaptors |
Target: | EGFR |
Receptor: | ErbB3 |
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