J-113863 [Cas No. 353791-85-2]
Catalog No:TA-T11699
Manufacturer:TargetMol
CAS No.:353791-85-2
Formula:C30H37Cl2IN2O2
MWt:655.44
€54,00 – €1.079,00
Name: | J-113863 |
Category: | Biochemicals |
Description: | J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptors. Anti-inflammatory effect. J-113863 is a potent and selective CCR1 (CD18) antagonist with IC50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively. |
Pathway: | Immunology & Inflammation,Microbiology & Virology |
Target: | CCR |
Receptor: | CCR1,CCR3 |
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